Phenotypes Associated with This Genotype

Genotype
MGI:3777342

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Traf2^tm1Rbr/Traf2^tm1Rbr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased follicular B cell number ( J:132877 )

• there is almost a 2-fold increase in the number of follicular B cells found in the spleen

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

lymph node hyperplasia ( J:132877 )

• about a 3-fold increase in the number of cells present in lymph nodes

• increase is due to expansion of the B cell compartment

hematopoietic system

increased follicular B cell number ( J:132877 )

• there is almost a 2-fold increase in the number of follicular B cells found in the spleen

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells