Phenotypes Associated with This Genotype

Genotype
MGI:3777112

• Allelic Composition: Atf4^tm1Tow/Atf4^tm1Tow
• Genetic Background: either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atf4^tm1Tow/Atf4^tm1Tow mice show pancreatic hypotrophy

cellular

abnormal osteoblast differentiation ( J:129974 )

• delay in differentiation

craniofacial

abnormal neurocranium morphology ( J:89403 )

• skull trabeculae were short and thin, putatively compromising the protection of the brain during delivery

large fontanelles ( J:89403 )

• widened at birth

abnormal frontal bone morphology ( J:89403 )

• decreased mineralization

abnormal parietal bone morphology ( J:89403 )

• decreased mineralization

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:129974 )

• number of acini is greatly reduced

• pancreatic acini are dispersed and are not in close proximity to neighboring acini resulting in an expanded extracellular space

• the centroacinar duct is greatly expanded in adults

abnormal pancreatic acinar cell morphology ( J:129974 )

• acinar cell size is greatly reduced

abnormal pancreatic acinar cell zymogen granule morphology ( J:129974 )

• acinar cells appear smaller with less zymogen granule content

exocrine pancreas hypoplasia ( J:89403 )

• exocrine pancreas of P4 mutants is severely underdeveloped

endocrine/exocrine glands

abnormal pancreas morphology ( J:129974 )

• adult pancreas contains numerous adipoctyes

abnormal pancreatic acinus morphology ( J:129974 )

• number of acini is greatly reduced

• pancreatic acini are dispersed and are not in close proximity to neighboring acini resulting in an expanded extracellular space

• the centroacinar duct is greatly expanded in adults

abnormal pancreatic acinar cell morphology ( J:129974 )

• acinar cell size is greatly reduced

abnormal pancreatic acinar cell zymogen granule morphology ( J:129974 )

• acinar cells appear smaller with less zymogen granule content

exocrine pancreas hypoplasia ( J:89403 )

• exocrine pancreas of P4 mutants is severely underdeveloped

skeleton

abnormal osteoblast differentiation ( J:129974 )

• delay in differentiation

abnormal neurocranium morphology ( J:89403 )

• skull trabeculae were short and thin, putatively compromising the protection of the brain during delivery

large fontanelles ( J:89403 )

• widened at birth

abnormal frontal bone morphology ( J:89403 )

• decreased mineralization

abnormal parietal bone morphology ( J:89403 )

• decreased mineralization

abnormal clavicle morphology ( J:89403 )

• decreased mineralization

decreased bone mineral density ( J:89403 )

abnormal bone trabecula morphology ( J:89403 )

• abnormal trabeculae

abnormal bone ossification ( J:89403 )

• normal skeletogenesis prior to E13, however defects were observed between E14 and E16

abnormal bone mineralization ( J:89403 )

• observed in both frontal and parietal bones, clavicles, and long bones