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Phenotypes Associated with This Genotype
Genotype
MGI:3776484
Allelic
Composition		 Il2rgtm2Cgn/Y
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm2Cgn mutation (0 available); any Il2rg mutation (132 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:132257 )
• 30% reduction in the number of NK cells found in the spleen 5 days after Cre induction
• 90% of the remaining NK cells still expressed IL2rg indicating they did not express Cre upon induction

hematopoietic system
decreased NK cell number ( J:132257 )
• 30% reduction in the number of NK cells found in the spleen 5 days after Cre induction
• 90% of the remaining NK cells still expressed IL2rg indicating they did not express Cre upon induction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory