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Phenotypes Associated with This Genotype
Genotype
MGI:3776115
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (13 available); any H2-Ab1 mutation (83 available)
Runx1tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (28 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:131081 )
• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells
abnormal interferon secretion ( J:131081 )
• after TCR stimulation, interferon gamma production is absent from class I-restricted CD4+CD8- cells

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:131081 )
• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory