Phenotypes for Runx1 Runx3 Tg(Cd4-cre)1Cwi MGI:3776111 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3⁺ Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3^tm1Itan mutation (1 available); any Runx3 mutation (28 available)
Tg(Cd4-cre)1Cwi mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:131081 )

• significantly lower than in controls

decreased CD8-positive, alpha-beta T cell number ( J:131081 )

• lower than in controls

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:131081 )

• significantly lower than in controls

decreased CD8-positive, alpha-beta T cell number ( J:131081 )

• lower than in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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