Phenotypes Associated with This Genotype

Genotype
MGI:3776064

• Allelic Composition: Nf1^tm1Par/Nf1^tm1Tyj; Tg(Mpz-cre)1Brn/0
• Genetic Background: involves: 129/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:131914 )

N • neural crest stem cells do not abnormally persist in the peripheral nervous system in adult mice

increased neurofibroma incidence ( J:131914 )

• at 15 - 20 months of age, all 6 mice examined had plexiform neurofibromas compared to 0 fibromas in control littermates

neoplasm

increased neurofibroma incidence ( J:131914 )

• at 15 - 20 months of age, all 6 mice examined had plexiform neurofibromas compared to 0 fibromas in control littermates