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Phenotypes Associated with This Genotype
Genotype
MGI:3776023
Allelic
Composition		 Krastm4Tyj/Kras+
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal epithelium morphology ( J:132357 )
• adult mice develop widespread hyperplasia throughout the colonic epithelium
abnormal large intestine crypts of Lieberkuhn morphology ( J:132357 )
• hyperplasia is typified by lengthening of the crypts in adult mice
abnormal colon goblet cell morphology ( J:132357 )
• large, prominent goblet cells develop in the colon in adult mice

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:132357 )
• hyperplasia is typified by lengthening of the crypts in adult mice
abnormal colon goblet cell morphology ( J:132357 )
• large, prominent goblet cells develop in the colon in adult mice

cellular
abnormal colon goblet cell morphology ( J:132357 )
• large, prominent goblet cells develop in the colon in adult mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory