Phenotypes for Cyp3a13 Del(5Cyp3a57-Cyp3a59)2Nki Tg(Vil1-CYP3A4)1Nki MGI:3775625 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cyp3a13^tm1Nki/Cyp3a13^tm1Nki Del(5Cyp3a57-Cyp3a59)2Nki/Del(5Cyp3a57-Cyp3a59)2Nki Tg(Vil1-CYP3A4)1Nki/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp3a13^tm1Nki mutation (4 available); any Cyp3a13 mutation (37 available)
Del(5Cyp3a57-Cyp3a59)2Nki mutation (0 available); any Del(5Cyp3a57-Cyp3a59)2Nki mutation (0 available)
Tg(Vil1-CYP3A4)1Nki mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:127366 )

• docetaxel M-2 metabolites are not detected in hepatic microsomes unlike in wild-type microsomes treated with docetaxel

• however, M-2 metabolites are detected in intestinal microsomes

• docetaxel accumulation in the small intestines is decreased 4-fold compared to in Del(15Cyp3a57-Cyp3a59)1Ahs Cyp3a13^tm1Ahs homozygotes following intravenous injection of docetaxel

• however, upon oral administration of docetaxel plasma levels are reduced 16.6 fold compared to in Del(15Cyp3a57-Cyp3a59)1Ahs Cyp3a13^tm1Ahs homozygotes

• oral bioavailability is decreased to 1.8% compared to 8.1% in wild-type mice

• clearance of docetaxel is reduced compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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