Phenotypes for Ctnnb1 Tg(Pdx1-cre)6Tuv MGI:3773346 MGI Mouse

mortality/aging

premature death ( J:119908 )

• shortened lifespan, with a median survival of 29 days, although some mice do survive more than 6 months

growth/size/body

decreased body size ( J:119908 )

• small body size at birth that persists into adulthood

endocrine/exocrine glands

abnormal pancreas morphology ( J:119908 )

• in 17% of mutants that survived beyond 3 months, the pancreas has a liver-like histology

abnormal exocrine pancreas morphology ( J:119908 )

• numerous tubular structures suggesting pancreas acinar to duct metaplasia, however islets are intact

pancreatic acinar hypoplasia ( J:119908 )

• acinar hypoplasia is seen by E16.5 and by 2 months of age, there is a near complete absence of acinar cell structures

decreased pancreas weight ( J:119908 )

• pancreas weighs on average 30% less than wild-type

pancreas fibrosis ( J:119908 )

• increase in parenchymal fibrosis

abnormal pancreas physiology ( J:119908 )

• decrease in the proliferation rate of pancreatic exocrine progenitors

pancreas inflammation ( J:119908 )

• variable degree of surrounding inflammatory infiltrate which becomes more severe by 1 month of age; inflammatory infiltrate is reminiscent of pancreatitis

immune system