Phenotypes Associated with This Genotype

Genotype
MGI:3772814

• Allelic Composition: Cd19^tm1(cre)Cgn/?; Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte morphology ( J:131076 )

• after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal lymphocyte cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent immature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal B cell morphology ( J:131076 )

• CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal splenic cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen

abnormal lymph node cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the lymph nodes

hematopoietic system

abnormal bone marrow cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal lymphocyte morphology ( J:131076 )

• after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal lymphocyte cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent immature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal B cell morphology ( J:131076 )

• CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal splenic cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen