Phenotypes Associated with This Genotype

Genotype
MGI:3772772

• Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym; n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased apoptosis ( J:130723 )

• in culture, macrophage cell death increases from 6.2% in wild-type cells and in Trsp null cells 31% to 53%

increased cellular sensitivity to oxidative stress ( J:130723 )

• production of oxygen reactive species is increased compared to when either gene product is absent

increased cellular sensitivity to hydrogen peroxide induced cell death ( J:130723 )

• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent

homeostasis/metabolism

increased cellular sensitivity to oxidative stress ( J:130723 )

• production of oxygen reactive species is increased compared to when either gene product is absent

increased cellular sensitivity to hydrogen peroxide induced cell death ( J:130723 )

• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent