Phenotypes Associated with This Genotype

Genotype
MGI:3772212

• Allelic Composition: Pou5f1^tm1Scho/Pou5f1^tm1Scho; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:130248 )

N • mesenchymal stem cells (MSCs) from mutant mice show normal proliferative capacity and lineage commitment

N • hematopoietic stem cells (HSCs) appear normal, and white blood cell (WBC), red blood cell (RBC) or platelet counts exhibit no deficiency

N • bone marrow displays normal B-cell, monocyte, and granulocyte lineages at 12 and 35 days after recombination

liver/biliary system

liver/biliary system phenotype ( J:130248 )

N • 2 months after removal of 75%, mutants were able to fully regenerate lost tissue, similar to wild-type