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Phenotypes Associated with This Genotype
Genotype
MGI:3771808
Allelic
Composition
Itktm1Litt/Itktm1Litt
Tg(DO11.10)10Dlo/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Litt mutation (2 available); any Itk mutation (51 available)
Tg(DO11.10)10Dlo mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• isolated T cells primed under Th2 conditions for 5 days, restimulated for 5 more days, then restimulated in absence of exogenous cytokine fail to produce Il4, although cell expansion is similar to wild-type; PMA/ionomycin restimulation of Th2-primed cells restores Il4 secretion

hematopoietic system
• isolated T cells primed under Th2 conditions for 5 days, restimulated for 5 more days, then restimulated in absence of exogenous cytokine fail to produce Il4, although cell expansion is similar to wild-type; PMA/ionomycin restimulation of Th2-primed cells restores Il4 secretion


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory