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Phenotypes Associated with This Genotype
Genotype
MGI:3771566
Allelic
Composition		 Ptf1atm1.1(cre)Cvw/CbllTg(Alb-KL)7-2Mhos
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CbllTg(Alb-KL)7-2Mhos mutation (0 available); any Cbll mutation (0 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop similar to CbllTg(Alb-KL)7-2Mhos homozygotes
abnormal GABAergic neuron morphology ( J:100997 )
• failure of GABA neurons to develop by 4 days after birth is similar to CbllTg(Alb-KL)7-2Mhos homozygotes

cellular
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop similar to CbllTg(Alb-KL)7-2Mhos homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory