Phenotypes Associated with This Genotype

Genotype
MGI:3771318

• Allelic Composition: Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln
• Genetic Background: FVB.Cg-Mapt^tm1(MAPT)Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:96869 )

• a motor deficit on beam walk test in all mice by 9-12 moths

• impaired in rotarod performance by age 9-10 months

• homozygous mice are indistinguishable from wild-type mice until 6 months old

• no clasping of limbs

nervous system

nervous system phenotype ( J:96869 )

N • axonal dilations were completely absent in brain and spinal cord at any age

N • reaction with thioflavin S or X-34 was completely absent confirming the total absence of tauopathy