Phenotypes Associated with This Genotype

Genotype
MGI:3770684

• Allelic Composition: Ngfr^tm1Jae/Ngfr⁺
• Genetic Background: B6.129S4-Ngfr^tm1Jae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:127639 )

• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfr^tm1Jae homozygotes

abnormal axon extension ( J:127639 )

• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfr^tm1Jae homozygotes

respiratory system

decreased airway responsiveness ( J:115419 )

• unlike in wild-type mice, no airway hyper-responsiveness was observed following exposure to Ach and ovalbumin (50% brionchiorestriction occurs at 580 ug per kg for Ach and 586 ug per kg ovalbulmin compared to 552 ug per kg Ach and 62.5 ug per kg ovalbumin for wild-type mice)

• total leukocytes, eosinophils and lymphocytes do not increase as in wild-type following exposure to provocation agent

• unlike in exposed wild-type mice, no pulmonary eosinophilic inflammation is observed

• unlike in exposed wild-type mice IL-4 and IL-5 production is not increased

• while IgE levels increase following exposure to provocation they do not increase as much as in wild-type mice

• however, interferon-gamma production following exposure to provocation agent is normal

cellular

abnormal neuron differentiation ( J:127639 )

• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfr^tm1Jae homozygotes

abnormal axon extension ( J:127639 )

• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfr^tm1Jae homozygotes