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Phenotypes Associated with This Genotype
Genotype
MGI:3770683
Allelic
Composition		 Sema3atm1Mcf/Sema3a+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3atm1Mcf mutation (0 available); any Sema3a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:127639 )
• at E12.5, peripheral nerves are not as severely stunted as in Ngfrtm1Jae Sema3atm1Mcf homozygotes
• at E12.5, neuron growth is increased 1.19-fold in hindlimbs, 1.25-fold in forelimbs and 1.19-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes

cellular
abnormal neuron differentiation ( J:127639 )
• at E12.5, peripheral nerves are not as severely stunted as in Ngfrtm1Jae Sema3atm1Mcf homozygotes
• at E12.5, neuron growth is increased 1.19-fold in hindlimbs, 1.25-fold in forelimbs and 1.19-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory