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Phenotypes Associated with This Genotype
Genotype
MGI:3770663
Allelic
Composition		 Itgb6tm1Des/Itgb6tm1Des
Genetic
Background		 either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:109367 )
• treatment with angiotensin II and aldosterone reduces macrophage invasion where as it increases macrophage invasion in wild-type mice
decreased susceptibility to injury ( J:109367 )
• tubulointerstitial damage and fibrosis induction are less than in wild-type mice following kidney obstruction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory