Phenotypes Associated with This Genotype

Genotype
MGI:3770647

• Allelic Composition: Itgb1^tm1Ref/Itgb1^tm1Ref; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet calcium level ( J:118488 )

abnormal platelet physiology ( J:118488 )

• while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets

• platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets

• platelet calcium response fluctuates and is lower than in wild-type platelets

homeostasis/metabolism

decreased platelet calcium level ( J:118488 )

abnormal platelet physiology ( J:118488 )

• while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets

• platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets

• platelet calcium response fluctuates and is lower than in wild-type platelets