Phenotypes Associated with This Genotype

Genotype
MGI:3770519

• Allelic Composition: Kras^tm2Tyj/Kras⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:68981 )

• mice have reduced life spans compared to Kras or Trp53 heterozygous mice, or Trp53 homozygotes

neoplasm

increased tumor incidence ( J:68981 )

• double mutants display more malignant features than Kras heterozygous tumors, with marked cellular pleomorphism and anaplastic changes with giant cell formation

• mice have broader tumor spectrum compared to Kras or Trp53 heterozygotes, including histocytic sarcoma, medulloblastoma, osteosarcoma, and teratoma

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: about 40% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

increased skin papilloma incidence ( J:68981 )

• about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

increased fibrosarcoma incidence ( J:68981 )

• about 30% of double mutants develop fibrosarcoma

increased hemangiosarcoma incidence ( J:68981 )

• about 30% of double mutants develop hemangiosarcoma

integument

increased skin papilloma incidence ( J:68981 )

• about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: about 40% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

hematopoietic system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: about 40% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

immune system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: about 40% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background