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Phenotypes Associated with This Genotype
Genotype
MGI:3769910
Allelic
Composition
Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2tm1Lau mutation (7 available); any Nos2 mutation (27 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)
• deposits are observed by 52 weeks of age (J:143551)
• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)
• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)
• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha
• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha
• neuronal loss in subiculum is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha
• widespread cortical neuron damage

behavior/neurological
• higher level of errors in day 2 of radial arm water maze in double mutant relative to single mutants Tg(APPSWE)2576Kha or homozygous Nostm1Lau

homeostasis/metabolism
• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)
• deposits are observed by 52 weeks of age (J:143551)
• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)
• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:112919


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory