Phenotypes Associated with This Genotype

Genotype
MGI:3769910

• Allelic Composition: Nos2^tm1Lau/Nos2^tm1Lau; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:112919 , J:143551 )

• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)

• deposits are observed by 52 weeks of age (J:143551)

• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

abnormal hippocampus CA3 region morphology ( J:143551 )

• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

loss of hippocampal neurons ( J:143551 )

• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

abnormal subiculum morphology ( J:143551 )

• neuronal loss in subiculum is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

decreased neuron number ( J:143551 )

neuron degeneration ( J:112919 )

• widespread cortical neuron damage

behavior/neurological

abnormal long-term spatial reference memory ( J:143551 )

• higher level of errors in day 2 of radial arm water maze in double mutant relative to single mutants Tg(APPSWE)2576Kha or homozygous Nos^tm1Lau

homeostasis/metabolism

amyloid beta deposits ( J:112919 , J:143551 )

• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)

• deposits are observed by 52 weeks of age (J:143551)

• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:112919