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Phenotypes Associated with This Genotype
Genotype
MGI:3769726
Allelic
Composition		 Tcf12tm3Zhu/Tcf12tm3Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:129570 )
• mice exhibit an accumulation of CD8+ single positive T cells

hematopoietic system
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:129570 )
• mice exhibit an accumulation of CD8+ single positive T cells

endocrine/exocrine glands
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory