Phenotypes Associated with This Genotype

Genotype
MGI:3769577

• Allelic Composition: Tbx15^de-H/Tbx15^de-H
• Genetic Background: B6EiC3 a/A-Tbx15^de-H/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal basioccipital bone morphology ( J:101708 )

• narrow basioccipital bone

decreased cranium height ( J:101708 )

decreased cranium width ( J:101708 )

• skull is narrower

abnormal mandibular angle morphology ( J:101708 )

• short angular process

short mandible ( J:101708 )

• in the lower jaw, the dentaries are shorter, with a short angular process

abnormal pectoral girdle bone morphology ( J:101708 )

• abnormal pectoral girdle

small acromion ( J:101708 )

• the acromion is reduced at E16.5

scapular bone foramen ( J:101708 )

• 100% penetrance

small scapula ( J:101708 )

• scapula is reduced in size and is more posteriorly and ventrally positioned at E13.5

abnormal cervical atlas morphology ( J:101708 )

• ectopic cartilage, including at this stage a tiny ossification center, is present at a corresponding position in the atlas

abnormal odontoid process morphology ( J:101708 )

• the dens of axis is reduced

abnormal vertebral arch morphology ( J:101708 )

• neural arches exhibit various abnormalities, including an axis with widened arches along the anteroposterior direction

craniofacial

abnormal basioccipital bone morphology ( J:101708 )

• narrow basioccipital bone

decreased cranium height ( J:101708 )

decreased cranium width ( J:101708 )

• skull is narrower

abnormal mandibular angle morphology ( J:101708 )

• short angular process

short mandible ( J:101708 )

• in the lower jaw, the dentaries are shorter, with a short angular process

abnormal ear position ( J:101708 )

• abnormal position of the ears

hearing/vestibular/ear

abnormal ear position ( J:101708 )

• abnormal position of the ears

growth/size/body

abnormal ear position ( J:101708 )

• abnormal position of the ears