Phenotypes Associated with This Genotype

Genotype
MGI:3769251

• Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺; Nr5a2^tm1Sjns/Nr5a2^tm1Sjns
• Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal feces lipid level ( J:129068 )

increased feces bile salt level ( J:129068 )

• following treatment with tamoxifen, bile acid in the feces is almost doubled in Nr5a2^tm2Sjns homozygotes due to an increase in lithocholic acid and hydrophobic secondary bile acids produced in the intestine by bacteria

abnormal intestinal lipid absorption ( J:129068 )

• following treatment with tamoxifen, mice exhibit lipid malabsorption

abnormal bile salt level ( J:129068 )

• following treatment with tamoxifen, the bile acid pool size is reduced as is the levels in the livers /gallbladders and intestines due to a reduction in cholic acid and tauroconjugated cholic acid while the levels of muricholic acid, ursodeoxycholic acid and their taurine conjugates are increased

digestive/alimentary system

abnormal feces composition ( J:129068 )

• following treatment with tamoxifen, feces lipid and bile acid content is increased

abnormal feces lipid level ( J:129068 )

increased feces bile salt level ( J:129068 )

• following treatment with tamoxifen, bile acid in the feces is almost doubled in Nr5a2^tm2Sjns homozygotes due to an increase in lithocholic acid and hydrophobic secondary bile acids produced in the intestine by bacteria

abnormal intestinal lipid absorption ( J:129068 )

• following treatment with tamoxifen, mice exhibit lipid malabsorption