Phenotypes Associated with This Genotype

Genotype
MGI:3769145

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: MRL.Cg-Irf1^tm1Mak Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:114771 )

• mice typically die by 26 weeks of age from renal failure; 50% of mice are dead by 22 weeks

renal/urinary system

increased urine protein level ( J:114771 )

• by 24 weeks of age, 75% of mice have urine protein levels >200 mg/dl

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show severe glomerulonephritis

renal glomerular immunoglobulin deposits ( J:114771 )

• mice show extensive glomerular deposition/staining of IgG and C3

kidney failure ( J:114771 )

• occurs around 26 weeks, leading to death

immune system

increased anti-double stranded DNA antibody level ( J:114771 )

• at 26 weeks of age, levels are significantly higher relative to Fas^lpr, Irf1-null mice

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show severe glomerulonephritis

homeostasis/metabolism

increased urine protein level ( J:114771 )

• by 24 weeks of age, 75% of mice have urine protein levels >200 mg/dl

integument

epidermal necrosis ( J:114771 )

• by 24 weeks, ear necrosis is observed in some mice

skin lesions ( J:114771 )

abnormal skin condition ( J:114771 )

• mice show characteristic signs of skin disease at 24 weeks of age

cellular

epidermal necrosis ( J:114771 )

• by 24 weeks, ear necrosis is observed in some mice