Phenotypes Associated with This Genotype

Genotype
MGI:3769144

• Allelic Composition: Fas^lpr/Fas^lpr; Irf1^tm1Mak/Irf1⁺
• Genetic Background: MRL.Cg-Irf1^tm1Mak Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:114771 )

• 50% of mice die by 52 weeks; survival is increased relative to MRL-Fas^lpr mice

renal/urinary system

increased urine protein level ( J:114771 )

• not significantly different from Fas^lpr, Irf1-null mice or Fas^lpr, Irf1-sufficient mice

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show much less severe renal disease including IgG and C3 glomerular deposition compared to Fas^lpr homozygotes

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:114771 )

• mice display similar T cell population profiles to Fas^lpr, Irf1-null mice

immune system

immune system phenotype ( J:114771 )

N • TNF alpha production is not significantly different Fas^lpr, Irf1-sufficient mice or Fas^lpr, Irf1-null mice

increased CD4-positive, alpha-beta T cell number ( J:114771 )

• mice display similar T cell population profiles to Fas^lpr, Irf1-null mice

increased anti-double stranded DNA antibody level ( J:114771 )

• at 26 weeks of age, levels are significantly higher relative to Fas^lpr, Irf1-null mice

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show much less severe renal disease including IgG and C3 glomerular deposition compared to Fas^lpr homozygotes

homeostasis/metabolism

increased urine protein level ( J:114771 )

• not significantly different from Fas^lpr, Irf1-null mice or Fas^lpr, Irf1-sufficient mice

integument

abnormal skin condition ( J:114771 )

• mice display varying severity of skin irritation ranging from little or none to mild or moderate to severe