Phenotypes Associated with This Genotype

Genotype
MGI:3768557

• Allelic Composition: Stat3^tm1Xyfu/Stat3^tm1.1Xyfu; Tg(Ttr-cre)10-3Xyfu/?
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:128719 )

• mortality during the first 12 hours following a 70% hepatectomy is 35.3% compared to 5.5% in Stat3^tm1Xyfu homozygotes

• however, mortality rates after 72 hours are similar

liver/biliary system

decreased hepatocyte proliferation ( J:128719 )

• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3^tm1Xyfu homozygotes

• however, liver regeneration following hepatectomy is completed

immune system

increased neutrophil cell number ( J:128719 )

• following carbon tetrachloride injection

increased monocyte cell number ( J:128719 )

• following carbon tetrachloride injection

hematopoietic system

increased neutrophil cell number ( J:128719 )

• following carbon tetrachloride injection

increased monocyte cell number ( J:128719 )

• following carbon tetrachloride injection

cellular

decreased hepatocyte proliferation ( J:128719 )

• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3^tm1Xyfu homozygotes

• however, liver regeneration following hepatectomy is completed