Phenotypes Associated with This Genotype

Genotype
MGI:3767842

• Allelic Composition: Nacc1^tm1Jabl/Nacc1^tm1Jabl
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:128447 )

• in response to cocaine, mice exhibit a blunted increase in locomotor activity compared to control mice

• the effect of amphetamine on locomotor activity is absent

• however, sensitization to cocaine or amphetamines is normal

impaired conditioned place preference behavior ( J:128447 )

• stimulant-induced conditioned place preference does not occur

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:128447 )

• following acute but not repeated exposure to cocaine, mice exhibit a blunted increase in extracellular dopamine levels compared to wild-type mice