Phenotypes Associated with This Genotype

Genotype
MGI:3767836

• Allelic Composition: Fgfr1^tm1Upir/Fgfr1^tm1Upir; Tg(Mnx1-GFP)1Slp/?; Tg(Nes-cre)1Kln/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome

abnormal motor neuron morphology ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome

• motor neuron axons are less fasciculated than in heterozygotes

• unlike in wild-type mice, motor neuron axons growth far into the dorsal root ganglia

cellular

abnormal axon guidance ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome