Phenotypes Associated with This Genotype

Genotype
MGI:3767614

• Allelic Composition: Tgfbr2^tm1Karl/Tgfbr2^tm1Karl; Tg(Tagln-cre)1Her/?; Gt(ROSA)26Sor^tm1Sor/?
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:128498 )

• mice die between E12.5 and E16.5; only resorbed homozygous embryos are recovered at E16.5

embryo

abnormal vitelline vasculature morphology ( J:128498 )

• while yolk sacs are normal at E9.5 by E12.5 yolk sacs are pale, anemic and possess obvious vasculature defects

embryonic growth retardation ( J:128498 )

pale yolk sac ( J:128498 )

• at E12.5, yolk sacs are pale and anemic

growth/size/body

embryonic growth retardation ( J:128498 )

cardiovascular system

abnormal vitelline vasculature morphology ( J:128498 )

• while yolk sacs are normal at E9.5 by E12.5 yolk sacs are pale, anemic and possess obvious vasculature defects

abnormal heart morphology ( J:128498 )

delayed heart development ( J:128498 )

• mice exhibit delayed underdeveloped hearts

nervous system

delayed brain development ( J:128498 )

• mice exhibit delayed underdeveloped brains