Phenotypes Associated with This Genotype

Genotype
MGI:3767595

• Allelic Composition: Fbxw7^tm1Kei/Fbxw7^tm1Kei; Tg(Lck-cre)1Cwi/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:128523 )

• mice that develop lymphomas die between 14 and 60 weeks

immune system

increased T cell apoptosis ( J:128523 )

• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased

enlarged thymus ( J:128523 )

increased double-positive T cell number ( J:128523 )

• the number and percent of double positive thymocytes is increased compared to in wild-type mice due to increased proliferation of double positive thymocytes

• however, the number and proliferation of double negative, CD4+ single positive and CD8+ single positive thymocytes are normal

arrested T cell differentiation ( J:128523 )

• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes

decreased single-positive T cell number ( J:128523 )

• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes

abnormal T cell activation ( J:128523 )

• T cells fail to proliferate in response to anti-CD3 or the combination of phorbol 12,13-dibutyrate and ionomycin

• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased

neoplasm

increased lymphoma incidence ( J:128523 )

• 12 of 23 mice develop aggressive lymphomas with massive thymic enlargement due to clonal expansion of double positive thymocytes

• tumors contain uniform populations of immature lymphoid cells with some areas of necrosis

• early and late onset tumors exhibit identical phenotype

hematopoietic system

increased T cell apoptosis ( J:128523 )

• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased

enlarged thymus ( J:128523 )

increased double-positive T cell number ( J:128523 )

• the number and percent of double positive thymocytes is increased compared to in wild-type mice due to increased proliferation of double positive thymocytes

• however, the number and proliferation of double negative, CD4+ single positive and CD8+ single positive thymocytes are normal

arrested T cell differentiation ( J:128523 )

• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes

decreased single-positive T cell number ( J:128523 )

• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes

abnormal T cell activation ( J:128523 )

• T cells fail to proliferate in response to anti-CD3 or the combination of phorbol 12,13-dibutyrate and ionomycin

• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased

cellular

increased T cell apoptosis ( J:128523 )

• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased

endocrine/exocrine glands

enlarged thymus ( J:128523 )