Phenotypes Associated with This Genotype

Genotype
MGI:3767477

• Allelic Composition: Ntf3^tm2Jae/Ntf3^tm2Jae; Tg(Nes-cre)1Atp/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellar foliation ( J:52951 )

• at P8, cerebellar foliation is defective

• at P8, folium VII and the posterior superior fissure are absent

• however, the formation of cerebellum layers and their associations with specific cell types is normal

abnormal cerebellar granule layer morphology ( J:52951 )

• at P8, apoptotic rates are 75% higher (37.3+/-11.4 cells per mm² compared to 21.3+/-6.98 cells per mm² in wild-type mice)

• however, there is no increase in apoptotic cells in the external germinal layer