Phenotypes Associated with This Genotype

Genotype
MGI:3767245

• Allelic Composition: Tlr7^rsq1/Tlr7^rsq1
• Genetic Background: C57BL/6J-Tlr7^rsq1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:128404 )

♀ • peritoneal macrophages from homozygous mutant female mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single-stranded RNA mimetic that normally activates TLR7

♀ • TNF-alpha production by homozygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, a TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, a TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand) or lipopolysaccharide (LPS, a TLR4 ligand)

decreased tumor necrosis factor secretion ( J:128404 )

♀ • peritoneal macrophages from homozygous mutant female mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single-stranded RNA mimetic that normally activates TLR7

♀ • TNF-alpha production by homozygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, a TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, a TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand) or lipopolysaccharide (LPS, a TLR4 ligand)

hematopoietic system

abnormal macrophage physiology ( J:128404 )

♀ • peritoneal macrophages from homozygous mutant female mice fail to produce tumor necrosis factor (TNF) alpha in response to R-848, a single-stranded RNA mimetic that normally activates TLR7

♀ • TNF-alpha production by homozygous mutant macrophages is normal following stimulation with macrophage activating lipopeptide 2 (MALP-2, a TLR2/6 ligand), CpG oligodeoxynucleotides (CpG ODN, a TLR9 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand) or lipopolysaccharide (LPS, a TLR4 ligand)