Phenotypes Associated with This Genotype

Genotype
MGI:3766601

• Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay
• Genetic Background: either: B6.129S7-Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal leukocyte tethering or rolling ( J:31374 )

• blocking of L-selection with monoclonal antibodies reduces rolling flux fraction of leukocytes to ~30 from 49%, but causes a greater reduction to ~6% in wild-type

increased leukocyte cell number ( J:31374 )

• systemic leukocyte counts are ~7670/ul (~62% neutrophils, ~36% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)

immune system

abnormal leukocyte tethering or rolling ( J:31374 )

• blocking of L-selection with monoclonal antibodies reduces rolling flux fraction of leukocytes to ~30 from 49%, but causes a greater reduction to ~6% in wild-type

increased leukocyte cell number ( J:31374 )

• systemic leukocyte counts are ~7670/ul (~62% neutrophils, ~36% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)

cellular

abnormal leukocyte tethering or rolling ( J:31374 )

• blocking of L-selection with monoclonal antibodies reduces rolling flux fraction of leukocytes to ~30 from 49%, but causes a greater reduction to ~6% in wild-type