Phenotypes Associated with This Genotype

Genotype
MGI:3766126

• Allelic Composition: Apc^tm1Rak/Apc⁺; Smad4^E6sad/Smad4⁺
• Genetic Background: B6.129P2-Apc^tm1Rak +/+ Smad4^E6sad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107273 )

• Background Sensitivity: all mice have died by 8 months of age due to complications arising from intestinal tumors

digestive/alimentary system

gastric polyps ( J:107273 )

• Background Sensitivity: in 100% of mice by 7 months of age

increased intestinal adenocarcinoma incidence ( J:107273 )

• Background Sensitivity: in two of seven mice, adenocarcinomas with invasion of the muscolaris mucosa are observed

increased intestinal adenoma incidence ( J:107273 )

• Background Sensitivity: by 7 months of age, mice present with an average of 20 tumors along the intestinal tract

• Background Sensitivity: tumors are mainly villous or tubulovillous adenomas with foci of severe dysplasia

neoplasm

increased intestinal adenocarcinoma incidence ( J:107273 )

• Background Sensitivity: in two of seven mice, adenocarcinomas with invasion of the muscolaris mucosa are observed

increased intestinal adenoma incidence ( J:107273 )

• Background Sensitivity: by 7 months of age, mice present with an average of 20 tumors along the intestinal tract

• Background Sensitivity: tumors are mainly villous or tubulovillous adenomas with foci of severe dysplasia