Mouse Genome Informatics
ht
    Timo/Timo+
either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• increase in both total amount and percent of body fat
• increase in both total amount and percent of body fat
• however, lean mass is similar to non-transgenic controls unlike in homozygous transgenic mice
• females and males are significantly heavier by 10 and 18 weeks of age, respectively, compared to non-transgenic controls
• females and males are 57 and 31% heavier than age-matched non-transgenic controls by 69 weeks of age
• increase in body weight is not as severe as in homozygous transgenic mice
• at 24 weeks of age, mean lengths of female and male mice are increased by about 7 and 3%, respectively

adipose tissue
• increase in both total amount and percent of body fat
• increase in both total amount and percent of body fat
• however, lean mass is similar to non-transgenic controls unlike in homozygous transgenic mice
• increase in the weight of the mesenteric fat pads

homeostasis/metabolism
• elevation in the LDL but not HDL or total, serum cholesterol levels

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:127183