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Phenotypes Associated with This Genotype
Genotype
MGI:3766125
Allelic
Composition
Timo/Timo+
Genetic
Background
either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females and males are significantly heavier by 10 and 18 weeks of age, respectively, compared to non-transgenic controls
• females and males are 57 and 31% heavier than age-matched non-transgenic controls by 69 weeks of age
• increase in body weight is not as severe as in homozygous transgenic mice
• at 24 weeks of age, mean lengths of female and male mice are increased by about 7 and 3%, respectively

adipose tissue
• increase in both total amount and percent of body fat
• however, lean mass is similar to non-transgenic controls unlike in homozygous transgenic mice
• increase in the weight of the mesenteric fat pads
• increase in both total amount and percent of body fat

homeostasis/metabolism
• elevation in the LDL but not HDL or total, serum cholesterol levels

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:127183


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory