Phenotypes Associated with This Genotype

Genotype
MGI:3766037

• Allelic Composition: Tg(Ins2-CD86)12B70Flv/0; Tg(Ins2-Tnf)17Flv/0
• Genetic Background: involves: C57BL/6 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:93555 )

• ~80% of animals show elevated blood glucose levels by 6 weeks of age

immune system

abnormal cytokine secretion ( J:93555 )

• frequency of Il4-positive cells in infiltrated islets increases as double transgenic mice become diabetic;frequency of Ifng-positive cells is higher than in double mutants expressing CD80 and Tnf

• frequency of Il4+, Th2 cells is dramatically reduced compared to single CD86 transgenic littermates

increased susceptibility to autoimmune diabetes ( J:93555 )

• all double mutants become diabetic, compared to single transgenic Tnf animals