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Phenotypes Associated with This Genotype
Genotype
MGI:3765975
Allelic
Composition		 Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1060 available)
Tg(GFP/KRAS2/ALPP)1Brn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased keratoacanthoma incidence ( J:127226 )
• upon induction with 4-hydroxytamoxifen (4-OHTA), 2/4 mice develop regional keratoacanthomas at site of drug application within 8 weeks
increased lymphoma incidence ( J:127226 )
• 2/4 induced animals acquire lymphoma
increased lung tumor incidence ( J:127226 )
• 2/4 induced animals acquire lung tumors

integument
increased keratoacanthoma incidence ( J:127226 )
• upon induction with 4-hydroxytamoxifen (4-OHTA), 2/4 mice develop regional keratoacanthomas at site of drug application within 8 weeks

respiratory system
increased lung tumor incidence ( J:127226 )
• 2/4 induced animals acquire lung tumors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory