Phenotypes Associated with This Genotype

Genotype
MGI:3765943

• Allelic Composition: Sfn^Er/Sfn^Er
• Genetic Background: B6CBACa A^w-J/A-Sfn^Er/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dorsal skin comparison of a wild type and Sfn^Er/Sfn^Er mouse

mortality/aging

perinatal lethality, complete penetrance ( J:102931 )

• die at birth due to respiratory stress

digestive/alimentary system

abnormal oral epithelium morphology ( J:102931 )

• fusion of the epithelium of the oral cavity

growth/size/body

abnormal oral epithelium morphology ( J:102931 )

• fusion of the epithelium of the oral cavity

respiratory system

respiratory distress ( J:102931 )

craniofacial

abnormal oral epithelium morphology ( J:102931 )

• fusion of the epithelium of the oral cavity

limbs/digits/tail

short limbs ( J:102931 )

• stumpy legs

short tail ( J:102931 )

• stumpy tail

integument

abnormal keratinocyte differentiation ( J:102931 )

• failure of keratinocyte terminal differentiation; epidermis cells do not differentiate into mature granular and cornified cells

absent epidermis stratum corneum ( J:102931 )

• the thickened epidermis lacks the stratum corneum

absent epidermis stratum granulosum ( J:102931 )

• the thickened epidermis lacks the stratum granulosum

epidermal hyperplasia ( J:102931 )

thick epidermis ( J:102931 )

shiny skin ( J:102931 )

cellular

abnormal keratinocyte differentiation ( J:102931 )

• failure of keratinocyte terminal differentiation; epidermis cells do not differentiate into mature granular and cornified cells