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Phenotypes Associated with This Genotype
Genotype
MGI:3765442
Allelic
Composition
Tg(SV40-NRAS*G12D)1Sco/?
Genetic
Background
Not Specified
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together
• during the first 6 months of life, 10 females and 17 males develop reticulum cell sarcoma type A while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

endocrine/exocrine glands
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

hematopoietic system
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together

immune system
• two female primary transgenic mice develop T cell lymphomas, one at 10 weeks and the other at 17
• during the first 6 months of life, 9 females and 3 males develop thymic T cell lymphomas while 10 females and 3 males develop thymic T cell lymphomas and reticulum cell sarcoma type A together


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory