Analysis Tools
mortality/aging
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• embryos are all dead by E14.5
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cardiovascular system
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• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
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• by E12.5, the myocardium has pulled away from the epicardium
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• by E12.5, large effusions are apparent around the embryonic heart
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• in E11.5 embryos, cardiac outputs are nearly 3 fold higher than in littermate controls
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• in E11.5 embryos, left ventricular stroke volume is 2.5 fold higher than in controls
• no evidence of valvular regurgitation is detected, indicating that excess flow is in the outward direction
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• maternal administration of a smooth muscle tone agonist rescues half of E14.5 embryos from lethality related to cardiac failure
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• at E12.5, 25% of embryos lack a heartbeat with the remaining embryos having a slower heartbeat (86 bpm vs 128 bpm)
• by E14.5 all embryos have lost their heartbeat
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embryo
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• at E12.5, some yolk sacs are poorly perfused while others are devoid of blood
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hematopoietic system
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• mice have normal amounts of erthyrocytes and do not display other signs of anemia
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homeostasis/metabolism
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• by E12.5, large effusions are apparent around the embryonic heart
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muscle
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• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
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