Phenotypes Associated with This Genotype

Genotype
MGI:3765430

• Allelic Composition: Egfr^tm1Wag/Egfr^tm1Wag
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:26834 )

• fewer mice than expected mice develop to term

postnatal lethality, complete penetrance ( J:26834 )

• Background Sensitivity: no mice survive until P20 unlike on a mixed 129 C57BL/6 MF1 background

embryonic lethality during organogenesis, incomplete penetrance ( J:26834 )

• fewer than expected mice are present at E11.5 and fewer mice than expected mice develop to term

embryo

decreased embryo size ( J:26834 )

• at E13.5, embryos are slightly reduced in size compared to controls

decreased embryo weight ( J:26834 )

• at E13.5, embryos are slightly reduced in weight compared to controls

abnormal placenta morphology ( J:26834 )

• at E13.5, placentas are structurally abnormal

• however, the labyrinthine trophoblast cells and the network of embryonic vessels and maternal sinuses appear normal

abnormal maternal decidual layer morphology ( J:26834 )

♀ • at E13.5, the maternal deciduas separates from fetal components more easily than in wild-type mice

decreased spongiotrophoblast size ( J:26834 )

• the spongiotrphoblast layer is reduced in size compared to in wild-type mice

small placenta ( J:26834 )

respiratory system

abnormal bronchiole epithelium morphology ( J:26834 )

• mice display undifferentiated epithelium in the respiratory bronchioles

abnormal pulmonary alveolus epithelium morphology ( J:26834 )

• mice display undifferentiated epithelium in the alveoli

thick pulmonary interalveolar septum ( J:26834 )

• the number of cells in the alveolar septum is increased compared to in wild-type mice

vision/eye

decreased cornea thickness ( J:26834 )

• at birth, the cornea is thin and fibrotic

eyelids open at birth ( J:26834 )

• at E16.5, eyes are open and by birth eyelids have failed to grow and fused

growth/size/body

decreased embryo size ( J:26834 )

• at E13.5, embryos are slightly reduced in size compared to controls

decreased embryo weight ( J:26834 )

• at E13.5, embryos are slightly reduced in weight compared to controls

reproductive system

abnormal maternal decidual layer morphology ( J:26834 )

♀ • at E13.5, the maternal deciduas separates from fetal components more easily than in wild-type mice

integument

abnormal hair follicle morphology ( J:26834 )

• at birth some hair follicles appear less differentiated

• however, the number of hair follicles and organization of the dermal layer are similar to in wild-type mice

abnormal vibrissa morphology ( J:26834 )

• at birth, whiskers are absent or only rudimentary stubs are present

absent vibrissae ( J:26834 )

abnormal epidermal layer morphology ( J:26834 )

• at E18.5, epidermal layers are not distinct

abnormal epidermis stratum corneum morphology ( J:26834 )

• at E18.5, the stratum corneum lacks keratinization

thin epidermis ( J:26834 )

• at E18.5