Phenotypes Associated with This Genotype

Genotype
MGI:3764520

• Allelic Composition: Fn1^tm4Hyn/Fn1^tm4Hyn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:126737 )

• Background Sensitivity: embryonic lethal with about 80% penetrance, 50% of E9.5 and 80% of E10.5 mutant embryos showed severe cardiovascular defects and were absorbed by E11.0 in mixed background compared to congenic strain of 129 or B6

cardiovascular system

abnormal placenta vasculature ( J:126737 )

• placental vascularization following the invasion with embryonic vessels was much less extensive in about 50% of mutant embryos

abnormal vascular development ( J:126737 )

• in severely affected mutant E9.5 embryos, dysmorphic large vessels in the head and small vessels in the head and body appeared syncytial with endothelial cells forming sheets instead of tubes

• in less severely affected, abnormally patterned, blunt-ended and constricted head veins

absent vitelline blood vessels ( J:126737 )

• in some embryos with blistered yolk sac

disorganized yolk sac vascular plexus ( J:126737 )

• in some embryos with blistered yolk sac

abnormal vascular smooth muscle morphology ( J:126737 )

• a decrease in the number of vascular smooth muscle cells in E10.5 embryos

abnormal cardiac outflow tract development ( J:126737 )

• thinned outflow tract in 30% of all defective embryos by E10.5

abnormal atrioventricular cushion morphology ( J:126737 )

• in some abnormal E10.5 embryos

distended pericardium ( J:126737 )

• in 50% of all defective embryos by E10.5

hemorrhage ( J:126737 )

• within the 83% of all defective embryos by E9.5 and 100% by E10.5

• focal head hemorrhage in a small number of morphologically normal E10.5 embryos

hematopoietic system

anemia ( J:126737 )

• in defective embryos due to leakage of blood by E9.5

nervous system

kinked neural tube ( J:126737 )

• shortened posterior, kinked neural tube in 5% of all defective embryos by E9.5

embryo

abnormal placenta vasculature ( J:126737 )

• placental vascularization following the invasion with embryonic vessels was much less extensive in about 50% of mutant embryos

absent vitelline blood vessels ( J:126737 )

• in some embryos with blistered yolk sac

kinked neural tube ( J:126737 )

• shortened posterior, kinked neural tube in 5% of all defective embryos by E9.5

abnormal visceral yolk sac morphology ( J:126737 )

• separation of endodermal and mesodermal layer resulting in blistered appearance of the yolk sac in 30% of all defective embryos by E9.5

disorganized yolk sac vascular plexus ( J:126737 )

• in some embryos with blistered yolk sac

abnormal vitelline vascular remodeling ( J:126737 )

• in some embryos with blistered yolk sac

muscle

abnormal vascular smooth muscle morphology ( J:126737 )

• a decrease in the number of vascular smooth muscle cells in E10.5 embryos