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Phenotypes Associated with This Genotype
Genotype
MGI:3763734
Allelic
Composition
Tg(Tyrp1-TAg)3434Bee/?
Genetic
Background
involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen
• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve
• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells
• tumor cells are poorly pigmented or nonpigmented
• however, islet of pigmented cells can be observed in the optic nerve

mortality/aging
• mice die at 11.6 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

neoplasm
• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen
• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve
• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells
• tumor cells are poorly pigmented or nonpigmented
• however, islet of pigmented cells can be observed in the optic nerve

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinal cancer DOID:4645 J:75629


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory