Phenotypes Associated with This Genotype

Genotype
MGI:3763539

• Allelic Composition: Egfr^tm1Msi/Egfr^tm1Msi; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125912 )

• reduced survival (50% versus 70% WT littermate controls) after two thirds partial hepatectomy

liver/biliary system

delayed liver regeneration ( J:125912 )

• in mice treated with poly I/C (to drive Cre expression), there is a reduction in number of proliferating hepatocytes 36 to 48 hours after two-thirds partial hepatectomy (PH)

• 7 days after PH, the liver-to-body weight ratio is lower compared to control mice

• 15 days after PH, there are no significant differences in the liver-to-bodyweight ratio indicating that after the initial delay mutant livers can complete regeneration

immune system

increased circulating tumor necrosis factor level ( J:125912 )

• higher levels in the serum are observed 24 hours after PH

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:125912 )

• higher levels in the serum are observed 24 hours after PH