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Phenotypes Associated with This Genotype
Genotype
MGI:3763097
Allelic
Composition		 Runx1tm1Tani/Runx1tm1Tani
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Tani mutation (1 available); any Runx1 mutation (34 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development
increased double-negative T cell number ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stag
decreased double-positive T cell number ( J:125959 )
• resulting from arrested T cell development
arrested T cell differentiation ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stage

hematopoietic system
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development
increased double-negative T cell number ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stag
decreased double-positive T cell number ( J:125959 )
• resulting from arrested T cell development
arrested T cell differentiation ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stage

endocrine/exocrine glands
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory