Phenotypes Associated with This Genotype

Genotype
MGI:3763087

• Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:126780 )

• one of mouse died following treatment with streptozotocin compared to 3 of 7 similarly treated wild-type mice

reproductive system

reproductive system phenotype ( J:170888 )

N • male germ cell proliferation is normal

abnormal male germ cell apoptosis ( J:170888 )

♂ • number of germ cells is decreased 2-fold

increased seminal vesicle weight ( J:170888 )

♂ • worsening with time

enlarged testis ( J:170888 )

♂ • at 3 months of age

increased Leydig cell number ( J:170888 )

♂

increased testis weight ( J:170888 )

♂ • at 3 months of age

increased sperm number ( J:170888 )

♂ • sperm count is increased compared to in wild-type mice

♂ • worsening with time

increased epididymis weight ( J:170888 )

♂ • worsening with time

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:126780 )

• mice are resistant to diet-induced obesity and show no evidence of glucose tolerance or insulin sensitivity

decreased circulating glucose level ( J:126780 )

• following injection with streptozotocin, surviving mice have glucose serum levels less than 250 mg/dl compared to above 500 mg/dl in similarly treated wild-type mice

increased circulating testosterone level ( J:170888 )

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:126780 )

• one of mouse died following treatment with streptozotocin compared to 3 of 7 similarly treated wild-type mice

growth/size/body

growth/size/body region phenotype ( J:126780 )

N • when injected with gold thioglucose, mice fail to develop obesity, have fat pads, and serum triglyceride levels similar to in untreated mice with no evidence of glucose tolerance or insulin sensitivity

decreased susceptibility to diet-induced obesity ( J:126780 )

• mice are resistant to diet-induced obesity and show no evidence of glucose tolerance or insulin sensitivity

endocrine/exocrine glands

increased seminal vesicle weight ( J:170888 )

♂ • worsening with time

enlarged testis ( J:170888 )

♂ • at 3 months of age

increased Leydig cell number ( J:170888 )

♂

increased testis weight ( J:170888 )

♂ • at 3 months of age

cellular

abnormal male germ cell apoptosis ( J:170888 )

♂ • number of germ cells is decreased 2-fold