Phenotypes Associated with This Genotype

Genotype
MGI:3762040

• Allelic Composition: Il1rl2^tm1Hblu/Il1rl2^tm1Hblu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal macrophage activation involved in immune response ( J:296074 )

• bone marrow derived macrophages exhibit reduced phagocytosis when incubated with labeled Streptococcus pneumoniae

immune system

abnormal macrophage activation involved in immune response ( J:296074 )

• bone marrow derived macrophages exhibit reduced phagocytosis when incubated with labeled Streptococcus pneumoniae

abnormal dendritic cell physiology ( J:296074 )

• cytokine induction in response to Il1f9 (IL-36gamma) is impaired in bone marrow-derived dendritic cells

normal phenotype

no abnormal phenotype detected ( J:126327 )

• mice display no overt phenotype including normal skin