Phenotypes Associated with This Genotype

Genotype
MGI:3762008

• Allelic Composition: Del(11Hoxb3-Hoxb4)1Karl/Del(11Hoxb3-Hoxb4)1Karl; Hoxa9^tm1Mrc/Hoxa9^tm1Mrc
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:126371 )

• while the number of colonies formed from cultured bone marrow cells is normal, the size of colonies formed is smaller than in wild-type mice

decreased bone marrow cell number ( J:126371 )

• 4.3+/-0.3x10⁶ cells in 2 femurs compared to 6.0+/-0.4x10⁶ cells in 2 wild-type femurs

• however, red and white blood cell and hematocrit levels are normal

increased hematopoietic stem cell number ( J:126371 )

• the number of hematopoietic stem cells (Lin-Sca-1+c-Kit+CD150+ and Lin-Sca-1+c-Kit+CD34-) in bone marrow is increased 3-fold compared to in wild-type mice

decreased spleen weight ( J:126371 )

• 46.3+/-2.3 mg compared to 96.3+/-4.4 g in wild-type mice and 81.4+/-3.2 mgin Hoxa9^tm1Mrc homozygotes

spleen hypoplasia ( J:126371 )

• 8.9+/-0.3x10⁷ cells compared to 22.0+/-2.1x10⁷ cells in wild-type mice and 15.5+/-0.8x10⁷ cells in Hoxa9^tm1Mrc homozygotes

growth/size/body

decreased body weight ( J:126371 )

• 22.7+/-0.9 g compared to 31.5+/-1.2 g for wild-type mice and 27.6+/-1.0 g for Hoxa9^tm1Mrc homozygotes

immune system

decreased spleen weight ( J:126371 )

• 46.3+/-2.3 mg compared to 96.3+/-4.4 g in wild-type mice and 81.4+/-3.2 mgin Hoxa9^tm1Mrc homozygotes

spleen hypoplasia ( J:126371 )

• 8.9+/-0.3x10⁷ cells compared to 22.0+/-2.1x10⁷ cells in wild-type mice and 15.5+/-0.8x10⁷ cells in Hoxa9^tm1Mrc homozygotes