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Phenotypes Associated with This Genotype
Genotype
MGI:3761838
Allelic
Composition
Cbfbtm1Itan/Cbfbtm1Itan
Tg(Lck-cre)1Cwi/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (39 available)
Tg(Lck-cre)1Cwi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 2 fold decrease in total number
• slightly increased levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• a small subset of T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
• very few CD8-positive T cells are found in the thymus
• increase in DP T cell due to reduced ability of T cell precursors to mature past double positive stage

hematopoietic system
• 2 fold decrease in total number
• slightly increased levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• a small subset of T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
• very few CD8-positive T cells are found in the thymus
• increase in DP T cell due to reduced ability of T cell precursors to mature past double positive stage

endocrine/exocrine glands


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory